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To overcome these resistance mechanisms in APL cells
2019-05-27
To overcome these resistance mechanisms in APL cells, a number of drugs have been tested. Tamibarotene is approximately 10 times more potent than ATRA as an in vitro inducer of differentiation, and is chemically more stable than ATRA [5]. Although the precise mechanism of the combination of tamibaro
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Obesity is not the only concern documented for BPA
2019-05-27
Obesity is not the only concern documented for BPA. Epidemiological studies have identified neurocognitive effects of BPA and newly incident coronary artery disease, and laboratory studies strongly suggest BPA is an ovarian toxicant. The rapidly rising evidence of adverse effects has prompted manufa
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Surgical intervention remains obligatory for hemodynamic ins
2019-05-27
Surgical intervention remains obligatory for hemodynamic instability, including shock secondary to renal bleeding, complex lacerations, renal pelvic, or ureteral injury, plus certain renovascular conditions. The prolonged warm ischemia that may occur when under renal neoplasty usually results in irr
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zip inhibitor Data on chloroquine resistance from Pakistan i
2019-05-24
Data on chloroquine resistance from Pakistan is scarce, even in the most recent global analysis. Nevertheless, in 2013, the emergence of the F1076L mutant of the gene—the zip inhibitor responsible for chloroquine resistance—in in Pakistan highlights the imminent threat of resistant . In 2015, the fi
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Countdown to concluded its tasks after the launch of its
2019-05-24
Countdown to 2015 concluded its tasks after the launch of its seventh global report at the Maternal Newborn Health conference in Mexico City, October, 2015. It is now relaunched as Countdown to 2030 (CD2030), retaining and enhancing the successful multi-institutional network with over a decade of he
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HBeAg positive patients older than years with persistently
2019-05-24
HBeAg-positive patients older than 40 years with persistently high or high to normal ALT levels may be diagnosed with significant hepatic necroinflammation or fibrosis. During treatment, the clinical significance of timing of HBeAg loss or seroconversion remains unclear. However, a longer duration o
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Your support for the official
2019-05-24
Your support for the , official journal of the Japan Heart Rhythm Society (JHRS) and the Asia Pacific Heart Rhythm Society (APHRS), is sincerely appreciated. We are pleased to announce that JOA has become an open access journal. Thus it is always available for readers online. All articles are acces
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br TIEMPO DE CAMBIOS LA REINVENCI N IDENTITARIA DE
2019-05-24
TIEMPO DE CAMBIOS: LA REINVENCIÓN IDENTITARIA DE DOS FELIGRESÍAS INDÍGENAS Hemos tenido ocasión de exponer que, en la capital mexicana, el tlaxilacalli de Acatla se habría favorecido notablemente del proceso de secularización de la parcialidad de San Pablo, que el arzobispo Montúfar condujo MK177
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Ante estas opiniones hay que
2019-05-24
Ante estas opiniones, hay que tomar en cuenta que: “investigaciones recientes muestran que los pueblos indígenas han emergido junto dihydroergotamine manufacturer procesos de revitalización étnica y cultural, que han transformado el escenario sociopolítico y han puesto en tela de juicio las antiguas
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In our survey the mean DEFS DMFS index was higher
2019-05-24
In our survey, the mean DEFS/DMFS index was higher for the 6-years-old group (17.18). During early development, younger children often have difficulty carrying out proper oral care due to their physical limitations. After 6 years of age, the exfoliation of primary teeth and the eruption of permanen
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br Acknowledgements br Introduction The
2019-05-23
Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–
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Human ether a go go related gene HERG encodes
2019-05-23
Human-ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly-activating delayed-rectifier potassium Asiatic acid that generate IKr. This outward potassium current is elicited during the plateau phase of action potentials and is required for repolarization [4]. After being translated in
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En muchos estudios fuera del campo posfundacional la referen
2019-05-23
En muchos estudios (fuera del campo posfundacional) la referencia PalMitoyl Tripeptide-1 Laclau proviene de teorizar el “discurso populista”. Existe un frecuente equívoco que es interpretar esto como una reducción a una especie de lenguaje populista. Al respecto, el esfuerzo de Laclau por establecer
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s6 kinase br Contribution br Acknowledgments and disclosures
2019-05-23
Contribution Acknowledgments and disclosures Introduction Following HSCT a complex immune reconstitution (IR) is observed. When the infused CD34+cells (CD34+i) begin to proliferate, an increase in peripheral blood s6 kinase is detected. Lymphocytes require more time than granulocytes in or
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glucose transport proteins br A hallmark of the past decade
2019-05-23
A hallmark of the past decade has been the remarkable progress made in reducing maternal and child mortality, an achievement credited in some measure to the Millennium Development Goals. The reduction in child deaths from an estimated 12·7 million under-5 deaths in 1990 to fewer than 6 million dea
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