• The modification of proteins with the small amino acid prote

  2020-06-10

  

  The modification of proteins with the small 76-amino 17 alpha hydroxylase protein ubiquitin (Ub) plays a central role in many key cellular processes. Ubiquitylation of a target protein requires the concerted action of a cascade of three enzymes (Figure 1). The ubiquitin-activating enzyme (E1) catal

• Alpha SYN has no direct effect

  2020-06-10

  

  Alpha-SYN has no direct effect on forskolin-induced CREB phosphorylation, but rather blocks the stimulation of CRE-mediated transcription in the nucleus. Previously we suggested that α-SYN can enter the nucleus and is present in both cytosolic and nuclear fractions without direct interaction between

• br Materials and methods br Statistical analysis

  2020-06-10

  

  Materials and methods Statistical analysis All statistical analyses were performed using SPSS software version 20. Protein Temafloxacin hydrochloride data of DNMTs and clinicopathological parameters were collected. Mann-Whitney U Test was used to assess the differential expression of nonparam

• Diacylglycerol kinases DGK and are lipid kinases that

  2020-06-10

  

  Diacylglycerol kinases (DGK) α and ζ are lipid kinases that limit diacylglycerol (DAG)-dependent activation pathways downstream of the TCR (Merida et al., 2015). Their upregulation in tumor infiltrating lymphocytes (TIL) has been linked to generation of hyporesponsive states that contribute to immun

• DDR was originally cloned by the group

  2020-06-10

  

  DDR1 was originally cloned by the group of Michele de Luca, at the time named TrkE. The Genoa-based research team identified the skin, and the keratinocytes in particular, as a major site of DDR1-binding activity [20]. DDR1 is also expressed in kidney, liver and lung (Fig. 2). The functional role of

• Instead of receptor interaction or GT activity we focused

  2020-06-10

  

  Instead of receptor interaction or GT activity, we focused on the CPD and autoprocessing. The CPDs from the 2 toxins are highly homologous: each cysteine protease targets an intramolecular substrate and mediates InsP6-induced autoprocessing to release the GTD into host cytosol.40, 41 However, TcdB i

• In studies directed toward the

  2020-06-09

  

  In studies directed toward the development of sequence-specific major-groove binding small dna staining [11], we desired a non-intercalating molecular scaffold that could direct attached moieties into the major groove. As an initial step toward this goal, we wished to study the DNA binding mode and

• In the belief that DNA based nanosensors

  2020-06-09

  

  In the belief that DNA-based nanosensors and DNA microarrays should be easier to operate, faster, more accurate and more economically viable than PCR-based techniques, an electrochemical DNA biosensor was designed for detection of G. boninense[9], [10]. This was developed based on a gold electrode m

• br Experimental section br Results br

  2020-06-09

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised stavudine did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by a

• br Collagens as new drivers of zebrafish

  2020-06-09

  

  Collagens as new drivers of zebrafish tissue regeneration Contrary to mammals, zebrafish possess very high regeneration capacities and thereby represent a versatile model to study tissue and organ regeneration. Adult fish can fully reconstruct their brain, spinal cord, retina, kidney, liver, panc

• br Results and discussion br Conclusion In

  2020-06-09

  

  Results and discussion Conclusion In this investigation, pharmacophore models of CK1 inhibitors were developed using a pharmacophore modeling protocol proposed by us. The optimal pharmacophore hypothesis, Hypo2, was adopted to retrieve potential CK1 inhibitors from the commercial chemical data

• ACE also known as Kininase II is an important enzyme

  2020-06-09

  

  ACE also known as Kininase II is an important enzyme of the Renin angiotensin ep4 antagonist system (RAAS) (Novo et al., 1987), it is believed to be a potent blood pressure regulator and also plays a crucial role in activation of the bradykinin receptor via inactivation of bradykinin which works to

• L-Glutamine Following DEX exposure the levels of CYP A

  2020-06-09

  

  Following DEX exposure, the levels of CYP1A1 protein and activity remained unchanged, as seen in our previous in vitro study (Burkina et al., 2013). Dasmahapatra and Lee (1993) reported that 3.9μgL−1 DEX, similar to our highest tested concentration, did not change CYP1A1 protein content. An increase

• br Materials and methods br Results br

  2020-06-09

  

  Materials and methods Results Discussion The main finding of the present study is that selective ETA and dual ETA/ETB receptor blockade markedly improve endothelium-dependent vasodilatation in patients with type 2 diabetes and vascular complications. The magnitude of improvement did not dif

• Increased leukocyte trafficking and infiltration of the

  2020-06-08

  

  Increased leukocyte trafficking and infiltration of the vascular wall are thought to provide a key stimulus for SMC activation and subsequent neointima formation in response to vascular injury [19], [20]. The essential trigger regulating the accumulation of leukocytes in the vessel wall is the upreg

15964 records 848/1065 page Previous Next First page 上5页 846847848849850 下5页 Last page