• Many processes can lead to changes in

  2020-12-24

  

  Many processes can lead to changes in soil P pools over time. Plant-available P (when measured as DGT P) decreased over time for the INORG-P treatment (Fig. 1a). Orthophosphate can be stabilised with cations such as calcium to produce insoluble phosphates, reducing plant-available P (Bünemann et al.

• In conclusion the data suggest that doses

  2020-12-24

  

  In conclusion, the data suggest that doses of COX-2 inhibitors and EP1 receptor antagonists which have previously been reported to exert disease modulating or antiepileptic drug potentiating effects do not negatively affect seizure control in temporal lobe epilepsy. The contrasting impact of the EP1

• Ultrasound is an acoustic wave with a frequency kHz that

  2020-12-24

  

  Ultrasound is an acoustic wave with a frequency >20 kHz that needs a medium to propagate [20]. Accompanied by the spread of an ultrasonic wave, a series of alternating cycles of compression and rarefaction emerge in the liquid medium. During the rarefaction cycle, microbubbles are formed because of

• Just as Dorin et al and

  2020-12-24

  

  Just as Dorin et al. [2] and Nguyen et al. [3] write in regard to their models, our static model can be used to estimate the affinities of cc-5013 to albumin and CBG. Dorin et al. [2] estimates the K, but not K, since they find that their model is not particular sensitive towards changes in K. Our

• In principle in vitro techniques for

  2020-12-24

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized dofetilide lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombinant DNA

• Most xenobiotics undergo biotransformation before being excr

  2020-12-24

  

  Most xenobiotics undergo biotransformation before being excreted. Such biotransformation is classified into two phases. In the first phase, the lipophilic substrate is oxidized by the cytochrome P-450 (CYP450) enzyme system, which introduces a single oxygen l-name into the molecule (Moutou et al.,

• Each of these substrate receptors

  2020-12-24

  

  Each of these substrate receptors belongs to a multigene family with tens, if not hundreds of members in plants, and with in part overlapping and in part differential substrate specificities [4]. The complexity of the system is nicely illustrated by the F-box protein and auxin receptor TRANSPORT INH

• Covalent inhibitors are well suited for targeting the E enzy

  2020-12-24

  

  Covalent inhibitors are well suited for targeting the E1 MHY1485 of Ubl modifications. Because the E1 enzymes in Ubl modifications, such as the SUMO E1 and Atg7, have a slow turnover rate (Boggio et al., 2004), prolonged inhibition can be achieved without requiring compounds to be stable in circulat

• br Conflicts of interest br Introduction G

  2020-12-23

  

  Conflicts of interest Introduction G protein-coupled receptors (GPCRs), form the largest human membrane protein family, with 800 members overall. Many druggable targets for treatment of common diseases involve GPCRs that mediate therapeutic effects of 34% of all marketed drugs (Hauser, Attwood

• ML-193 ATRX belongs to the switch sucrose non fermenting SWI

  2020-12-23

  

  ATRX belongs to the switch/sucrose non-fermenting (SWI/SNF) chromatin remodeling family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression (Gibbons et al., 1995). Most of these mutations are located in two highly conserved regions of the ATRX protein: a

• thereby The unique property of mutant

  2020-12-23

  

  The unique property of mutant IDH1/2 in producing an oncometabolite that has no known physiological function makes mutant IDH enzymes as obvious potential therapeutic targets for the treatment of IDH-mutated tumors (Rohle et al., 2013, Wang et al., 2013). Clinical studies have also suggested the pre

• The annotation is arguably the

  2020-12-23

  

  The annotation is arguably the most important part of analysis, as it enables one to evaluate and interpret the content of the transcriptome assembly. In this context, the non-redundant contigs were initially run in BLAST against the Nr database showing that 55% of them displayed high similarity to

• beta lactamase inhibitor A series of monocarboxylated chalco

  2020-12-23

  

  A series of monocarboxylated chalcones (e.g. compounds 7 and 8, Fig. 2A) was previously identified as good CysLT1 antagonists [20], and none of them exhibited CysLT2 antagonistic activities (Supplementary Table S1). This study was consistent with reported result that CysLT2 beta lactamase inhibitor

• br P Y receptor structure br

  2020-12-23

  

  P2Y receptor structure Pharmacology Several subtype selective compounds have been developed in recent years (Jacobson and Müller, 2016; Rafehi and Müller, 2018). These compounds are helpful tools for analyzing the roles of P2Y receptor subtypes in physiology and pathophysiology. The present ar

• The mutation in Caucasian people of European heritage

  2020-12-23

  

  The Δ32 mutation in Caucasian people of European heritage is quite common but extremely rare in Asian and African countries (Huang et al., 1996). We recently reported the presence of this mutation from India (Husain et al., 1998a) and established the complete inheritance pattern (Husain et al., 1998

15194 records 701/1013 page Previous Next First page 上5页 701702703704705 下5页 Last page