• The present study was the first to examine how

  2021-04-17

  

  The present study was the first to examine how COMT genotype and estradiol are associated with L189 receptor functioning in healthy postmenopausal women. We hypothesized that with decreased circulating estradiol after menopause, the COMT genotype relationship to cognition would remain and perhaps b

• br Acknowledgements This work was supported by

  2021-04-17

  

  Acknowledgements This work was supported by a grant from the Deutsche Forschungsgemeinschaft to Uwe Knippschild and Martin Wabitsch (SFB 1149/B4). P. Fischer-Posovszky is funded by a Margarete von Wrangell scholarship financed by the Ministerium für Wissenschaft, Forschung und Kunst Baden-Württem

• br Introduction Estrogens play an important

  2021-04-17

  

  Introduction Estrogens play an important role in the glibenclamide (Arevalo et al., 2015). During several decades, estrogen withdrawal in women has been associated with cognitive impairment, increased Alzheimer's disease (AD) risk (Pike, 2017) and with psychiatric disorders such as schizophrenia

• br Epac in cardiovascular pathophysiology Epac

  2021-04-17

  

  Epac in cardiovascular pathophysiology Epac orchestrates signaling actors that regulate fundamental cellular functions and general biological effects. However, some important gaps still remain in the knowledge of the physiopathological role of Epac in the heart. So far, Epac has been implicated i

• br Acknowledgements br Introduction Supramolecular collagen

  2021-04-17

  

  Acknowledgements Introduction Supramolecular collagen assemblies are crucial for the mechanical stability of animal bodies (Myllyharju and Kivirikko, 2004). The basic collagen structure is a triple helix of three chains containing multiple Gly-X-X' repeats; X and X' are often proline and 4-hy

• Fatostatin A It is interesting to note

  2021-04-17

  

  It is interesting to note that Eibinger and colleagues [23] recently reported chemotactic movement to 25-OHC in THP1 cells as well as in primary human monocytes. RNA interference suggested that in part this migration was mediated by EBI2. Competing financial interest statement Acknowledgments

• Introduction Double strand break DSB is the

  2021-04-17

  

  Introduction Double strand break (DSB) is the most deleterious damage that threats DNA integrity. This frequent damage arises from environmental stress like UV, chemical agents or ionizing radiations (IRs). Although environmental stress does not lead directly to DSB, it produces na inhibitor damage

• prostaglandin receptor DNA hypomethylation has been found in

  2021-04-17

  

  DNA hypomethylation has been found in liver tumor and other tumors of humans, such as laryngeal cancer, prostaglandin receptor tumors, tongue squamous cell carcinoma and uterine leiomyomas [[20], [21], [22], [23], [24]]. Then, we mainly sought to confirm whether TCA could induce DNA hypomethylation

• Cucurbitacin I For a physiologically relevant interaction li

  2021-04-17

  

  For a physiologically relevant interaction, ligand and receptor have to be expressed in the same place. Collagen II is found primarily in cartilage. DDR2 is expressed in proliferating chondrocytes in vivo, and its staining pattern in tibial growth plates is similar to that of collagen II. In additio

• br Experimental procedures br Introduction Protein

  2021-04-17

  

  Experimental procedures Introduction Protein kinases represent one of the largest enzyme glycogen synthase kinase 3 in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase a

• br Materials and methods br Results br Discussion

  2021-04-17

  

  Materials and methods Results Discussion TP has aroused extensive explorations because of its potent anti-inflammatory, immune-suppressive and antitumor activities. Notwithstanding these, TP has yet to enter Phase II clinical trials owing to its severe toxicity (Zhou et al., 2012). TP could

• Based on the ability of CRF to

  2021-04-17

  

  Based on the ability of CRF to modulate nociception, we hypothesized that stress leads to hyperalgesia by the activation of CRF1 and/or CRF2 receptors in the spinal cord. We tested this hypothesis using an acute forced swim as a widely used and easily reproducible stressor and grip force as a measur

• This paper proposes an acceptance process and evaluation cri

  2021-04-16

  

  This paper proposes an acceptance process and evaluation criteria, specialized for the dedication of indirect COTS SW as well as direct ones. (Step 1) It first recognizes an indirect COTS SW as a target of dedication, unlike EPRI NP-5652/TR-106439. (Step 2) It then determines the safety category of

• W-7 hydrochloride australia The BDNF Val Met polymorphism is

  2021-04-16

  

  The BDNF Val66Met polymorphism is also associated with decreased dendritic arborization and impaired long-term potentiation [25]. This is particularly important for the hippocampus, and healthy individuals with a BDNF Val66Met allele have decreased hippocampal volumes [30]. Hippocampal atrophy is co

• The immune control of CMV replication

  2021-04-16

  

  The immune control of CMV replication in vivo is primarily driven by the T-cell-mediated response, a characteristic that has been proposed as a tool to individualize and therefore to optimize antiviral treatment [6], [7], and it has been associated with spontaneous clearance of CMV viraemia in patie

15851 records 682/1057 page Previous Next First page 上5页 681682683684685 下5页 Last page