• The use of inhibitors clearly has its

  2021-07-02

  

  The use of inhibitors clearly has its caveats and the field should come to a consensus on etomoxir concentration to maximally block LC-FAO while minimalizing off-target effects. The current papers convincingly show that 200 μM is too high, but it should be noted that 3 μM does not fully suppress LC-

• The use of AACSB accreditation as an indicator of

  2021-07-02

  

  The use of AACSB accreditation as an indicator of expected performance on the CPA exam has been examined by prior studies (e.g. Barilla et al., 2008, Boone et al., 2006, Grant et al., 2002, Howell and Heshizer, 2006, Lindsay and Campbell, 2003, Marts et al., 1998). While these studies are based on d

• Another significant finding in our study was the demonstrati

  2021-07-02

  

  Another significant finding in our study was the demonstration that the axon-protective action associated with CK2 inhibition correlated with preservation of mitochondrial structure and function in mibefradil (Fig. 11). Because of the consistent protection conferred by CK2 inhibition during OGD, im

• No effect on the A production by

  2021-07-02

  

  No effect on the Aβ production by γ-secretase was observed at 50μM, the highest effective concentration used in cultured RG2833 by the study of Flajolet et al. IC261 did also not exert a modulatory effect on the production of Aβ, Aβ and Aβ species in the cell-free assay at this concentration. γ-Secr

• br Introduction Estrogens play an

  2021-07-02

  

  Introduction Estrogens play an important role in the 5224 (Arevalo et al., 2015). During several decades, estrogen withdrawal in women has been associated with cognitive impairment, increased Alzheimer's disease (AD) risk (Pike, 2017) and with psychiatric disorders such as schizophrenia (Kulkarn

• In agreement with the evidence

  2021-07-02

  

  In agreement with the evidence on the Plg-binding function of tapeworm enolases, eukaryotic enolases have been shown to be multifunctional proteins, with other activities besides their role as glycolytic enzymes (Pancholi, 2001). In this respect, several flatworms have been proved to express enolase

• Recent advances in microarray and

  2021-07-02

  

  Recent advances in microarray [32] and next-generation sequencing [33] based technologies have led to tremendous increases in information about the molecular mechanisms that are responsible for malignant transformation of rare and poorly understood soft tissue sarcomas. However, data interpretation

• br Transparency document br Introduction The cyclic nucleoti

  2021-07-02

  

  Transparency document Introduction The cyclic nucleotide adenosine 3′,5′-cyclic monophosphate (cAMP) exerts both an endothelium-dependent and an endothelium independent vasorelaxant action in rat H-Lys(Ac)-OH.HCl [1]. cAMP direct, endothelium-independent vasorelaxant effects have been attrib

• br Methods br Results br Discussion The findings of

  2021-07-02

  

  Methods Results Discussion The findings of this study indicate that an ET system including ET-1 and ET-2 as well as ET receptors are present in the retina and RPE/choroid, and are up-regulated by both hypertension and diabetes. Specifically, individual antagonism of the ETRA or ETRB deliver

• Orange spotted grouper Epinephelus coioides is a coral reef

  2021-06-29

  

  Orange-spotted grouper (Epinephelus coioides) is a coral reef fish with a high commercial value in China and Southeast Asian countries. However, in recent years, various outbreaks of viral diseases have affected the grouper aquaculture industry (Wei et al., 2010). Specifically, Singapore grouper iri

• According to this theory the chemical potential of the

  2021-06-29

  

  According to this theory, the chemical potential of the basic hydrate in the equilibrium condition can be calculated as: , and denote the chemical potentials of the basic hydrate, water and gas, respectively. Also, is the number of gas molecules per water molecules in the basic hydrate. After su

• Sex has been shown to mediate the relationship between

  2021-06-29

  

  Sex has been shown to mediate the relationship between allelic differences in COMT and behavior (Harrison & Tunbridge, 2008). The COMT promoter region contains 2 estrogen response elements (Xie, Ho, & Ramsden, 1999) that can inhibit the formation of COMT (Jiang, Xie, Ramsden, & Ho, 2003). With regar

• br Materials and methods br Results

  2021-06-29

  

  Materials and methods Results Recombinant, N-terminally His6-tagged vCPH was purified to near homogeneity via a modification of the reported procedure and its identity confirmed by intact protein mass spectrometry (Supplementary Fig. 1). As reported, vCPH catalysed two hydroxylations of a PAPK

• The role of activation of

  2021-06-28

  

  The role of activation of xenosensor nuclear receptors such as PPARα, CAR, and PXR in producing hepatomegaly and liver tumors in rodents has been well-established (Klaunig et al., 2003, Lake, 2009). In the case of PPARα, the increase in liver weight results from increased peroxisomal mass and expans

• br Acknowledgments br Introduction Inflammation is the prote

  2021-06-28

  

  Acknowledgments Introduction Inflammation is the protective reaction of the body to infection, injury, or irritation with the aim to remove harmful stimuli such as pathogens, damaged cells, or allergic irritants and to initiate the healing process. Inflammatory abnormalities play a crucial rol

15202 records 597/1014 page Previous Next First page 上5页 596597598599600 下5页 Last page