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In contrast the role of CRF receptors
2020-07-29
In contrast, the role of CRF2 receptors in anxiety behavior is less clear. For example, behavioral differences were noted in three recent CRF2 knockout studies. Using open-field center exploration as a measure, one study reported that CRF2 knockout mice showed increased center activity [27], another
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fiin The boiling point of bitumen cannot
2020-07-29
The boiling point of bitumen cannot be precisely measured, because bitumens contain extremely heavy fractions. For instance, 50 wt% of Athabasca bitumen possesses a nominal boiling point exceeding 797 K [25]. These fractions are not distillable even under vacuum pressures, because the boiling point
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PSB 0777 ammonium salt br Results and discussion br Conclusi
2020-07-29
Results and discussion Conclusion Experimental section Pharmacological studies Introduction Survival analysis is a set of statistical methods that aim at modeling the relationship between a set of predictor variables and an outcome variable and, in particular, prediction of the time w
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br Results br Discussion HR of two ended DSBs can
2020-07-28
Results Discussion HR of two-ended DSBs can proceed by two different sub-pathways. One of the pathways involves extended DNA repair synthesis, the formation of a dHJ, and crossover formation, while the other HR sub-pathway, SDSA, prevents the formation of a dHJ by displacing the invading stran
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Another emerging approach is the
2020-07-28
Another emerging approach is the live cell imaging, tracking the behavior of the fluorescently labeled proteins after laser micro irradiation [2]. Mari et al. demonstrated that the accumulation of XRCC4 in irradiated area was dependent on Ku but not on DNA-PKcs [23]. Yano et al. showed that the accu
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While linear sequences are important they
2020-07-28
While linear sequences are important, they must be viewed with some caution. One noteworthy example is the C1 domains which have attracted some interest as they are known to bind phorbol esters and DAG (reviewed in (Das and Rahman, 2014)). In this, it was not unreasonable to suspect that one or more
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Next we tried to specifically
2020-07-28
Next, we tried to specifically inhibit DDR2 function in endochondral proliferation and ossification in vivo. We used competitive inhibition with KD-Ddr2 overexpression specifically in cartilage cells, because it is generally difficult to regulate genes by miRNA in vivo. We constructed a transgenic v
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Arsenic could cause apoptosis in both benign
2020-07-28
Arsenic could cause apoptosis in both benign and malignant cells (Akao et al., 2000, Gupta et al., 2003, Namgung and Xia, 2001). However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related proteins. In addition, the alter
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The promoter region of the detoxifying gene GSTP
2020-07-28
The promoter region of the detoxifying gene, GSTP1, is commonly hypermethylated in the promoter region in prostate adenocarcinoma and hepatocellular carcinoma,38, 39 but it was not hypermethylated in either oral cancer tissue, adjacent mucosa, or normal oral mucosa, as previously reported. The regul
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The term myeloproliferative disorders was first proposed by
2020-07-28
The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myeloproliferative dis
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Cilengitide Introduction Progesterone also known as P is
2020-07-28
Introduction Progesterone, also known as P4, is a steroid hormone acting as a key component in the complex regulation of female reproductive function. P4 plays major physiological roles in the uterus and ovary by releasing mature oocytes helping in Cilengitide and maintenance of pregnancy, as well
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br Acknowledgement br Introduction CK kinases
2020-07-28
Acknowledgement Introduction CK2 kinases are ubiquitous highly conserved pleiotropic protein kinases (PKs) that have roles in various essential and pathological biological processes.1, 2, 3, 4, 5, 6, 7 In mammals the CK2 serine/threonine kinase family is composed of 2 enzymes, CK2α and CK2α’.
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The applications of fungal enzymes in paper industry involve
2020-07-27
The applications of fungal enzymes in paper industry involve biobleaching of pulp, pulp de-inking, degradation of dissolved and suspended organic compounds in concentrated effluents of mills and enhanced fibrillation. Enzymes usage is encouraged in paper industry in order to reduce the use of chemic
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Other GPCRs that have been described in B ALL
2020-07-27
Other GPCRs that have been described in B-ALL include oncogenic roles for the prostaglandin receptor PTGER2 [34], [35], [36], [37] and orphan receptor GPR34 [38], increased protein expression of the thrombin receptor F2R (also known as PAR1) at significantly higher levels than lymphocytes from healt
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Alternatively expanding efforts are focusing on the producti
2020-07-27
Alternatively, expanding efforts are focusing on the production of these UFAs in seeds of agronomically suitable plants, particularly oil crops by metabolic engineering (Damude and Kinney, 2008, Dyer and Mullen, 2008, Napier and Graham, 2010). A number of variant FAD2s (or Δ12 desaturases) have been
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