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The physiological role of lactate induced antilipolytic effe
2021-09-29
The physiological role of lactate-induced antilipolytic effects is less clear. It has been speculated that GPR81 mediates the inhibition of lipolysis during intensive exercise, a condition which results in high systemic lactate plasma concentrations 9, 10. Owing to oxygen shortage resulting from int
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In summary our findings support the hypothesis that activati
2021-09-29
In summary, our findings support the hypothesis that activation of GPR55 protects against deficits in neurogenesis induced by inflammatory insult both in vitro and in vivo through direct targeting of NSCs. Better understanding of the mechanisms by which GPR55 provides neuroprotection is critically n
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br Materials and methods br Results
2021-09-29
Materials and methods Results Discussion Previously, it is well known that methionine and choline deficient (MCDD) or choline-deficient, L-amino acid-defined (CDAA) models are widely accepted in NASH research. MCDD or CDAA dietary model has been mimic human NASH in rodents by sequentially p
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br Introduction In the treatment of patients with AIDS and
2021-09-29
Introduction In the treatment of patients with AIDS and human immunodeficiency virus type 1 (HIV-1), anti-retroviral therapy (ART), which uses anti-HIV drugs such as protease inhibitors, integrase inhibitors and reverse transferase inhibitors, has made a major contribution. There are still some s
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SGCs tightly ensheath the soma of DRG neurons Costa and
2021-09-29
SGCs tightly ensheath the soma of DRG neurons (Costa and Moreira, 2015, Hanani, 2005, Takeda et al., 2009). Intimate associations between SGCs and neurons facilitate bidirectional regulation of SGC function and neuronal excitability. After nerve injury, neuronal hyperexcitability can result in SGC a
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Necrosulfonamide br Acknowledgment br Introduction Positive
2021-09-29
Acknowledgment Introduction Positive and negative reinforcement are known as the two pivotal components in various models of drug dependence. Compulsive drug seeking behavior results from both the euphoric effects of drug use (positive reinforcement) and the unpleasant withdrawal signs followi
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Extending time action is another strategy to increase in
2021-09-29
Extending time action is another strategy to increase in vivo efficacy. Twice daily administration of the unacylated analogs herein caused greater body weight loss in DIO mice than the equivalent dose administered as a single daily injection, suggesting that protracted time action should yield more
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Mexiletine HCl In addition to inactivation of Notch we found
2021-09-28
In addition to inactivation of Notch, we found that the combination of BTZ and GSI-I downregulated ERK phosphorylation in ALK+ ALCL cells, and we speculate this may occur through the inhibition of upstream regulators of the ERK pathway. These findings emphasize the functional complementation of the
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In addition at the spinal level results from colocalization
2021-09-28
In addition, at the spinal level, results from colocalization experiments demonstrate that GABA-C receptors are present in the substantia gelatinosa and that they are presynaptically located. Neurons located in the substantia gelatinosa are differentially activated by afferent noxious and non-noxiou
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Similarly spectrophotometric titrations were carried out
2021-09-28
Similarly, spectrophotometric titrations were carried out under conditions identical to those used for the fluorescence titrations. exhibited a predominant Nicotinic Acid mg band at around 493 nm. The titrations with all G-quadruplex DNAs resulted in a hypochromic effect along with a bathochromic sh
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Our present data together with
2021-09-28
Our present data together with other studies have shown that the communication of stroma and cancer cells via ECM-cell interaction led to the primary activation of FAK [41]. Here we propose a model depicting an important role of ADAM12-L in the regulation of ESCC invasion and metastasis. ADAM12-L ov
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Recent advances in imaging single protein mobility and organ
2021-09-28
Recent advances in imaging single protein mobility and organization in live organisms such as Drosophila larva motor nerve terminals have initiated this by providing a useful platform to investigate how the dynamic changes in the actomyosin network correlates with vesicle docking and fusion in vivo2
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br Transportation from TGN toward
2021-09-28
Transportation from TGN toward plasma membrane The insulin molecules are packaged along with other molecules such as C-peptides, amylin, Zn2+, ATP and GABA in synaptic-like macrovesicles (SLMVs, with the diameters of 50–100 nm) and large dense core vesicles (LDCVs, with the diameters of 200–500 n
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br Funding The research for this paper
2021-09-28
Funding The research for this paper is conducted as part of a PhD thesis at Pasteur Institute of Iran and it was financially supported by Pasteur Institute of Iran and the Iranian Centre for Communicable Diseases. Conflict of interest Acknowledgments Introduction The viral enzyme integr
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Following the discovery of diketo
2021-09-28
Following the discovery of β-diketo compounds S-1360 [31] and L-731988 [32] as anti-HIV integrase inhibitors, a group of researchers discovered a potent PI-3065 based derivative (1) as the inhibitor of HIV integrase functioning at the 3′-processing and strand transfer steps of HIV integrase. Bioass
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