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br Modulators of the GUCY C
2021-10-25
Modulators of the GUCY2C/cGMP/PDEs signaling pathways for CRC prevention and therapy (pre-clinical and clinical development) Several modulators of the GUCY2C/cGMP/PDEs signaling pathways, including GUCY2C agonists and PDEs inhibitors, have been developed and explored as chemopreventive agents for
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L-741,626 br Acknowledgments This research was partially
2021-10-25
Acknowledgments This research was partially supported by the National Key Research and Development Program of China (2018YFD1000800); the National Natural Science Foundation of China (No. 31872943; No. 31501779 and No. 31372059>); 12th Five-Year State Science and Technology Support Program (2014B
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br The mode of binding of ligands to GPR
2021-10-25
The mode of binding of ligands to GPR35 As noted above, although kynurenic CGS 21680 is an agonist at GPR35, this is true for neither kynurenine [8] nor kynurenic acid ethyl ester [13]. This implicates a key role for the carboxylate group in binding and/or activation of GPR35. Importantly, in st
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Acknowledgements br Introduction The neurotransmitter glycin
2021-10-25
Acknowledgements Introduction The neurotransmitter glycine acts through two receptors: a strychnine-sensitive glycine receptor (GlyA) and a strychnine-insensitive glycine receptor (GlyB). GlyA is localized to the neuronal membrane post-synaptic to inhibitory glycinergic neurons, whereas GlyB is
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Molecular dynamics studies have proved an effective
2021-10-25
Molecular dynamics studies have proved an effective means of characterising transition state pathways between the inward- and outward-facing states, and providing the relative propensity for each state. For example, long-timescale simulations of the membrane-embedded LeuT dimer, totalling ∼21 μs, ha
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Initial studies generally focused on the co administration
2021-10-25
Initial studies generally focused on the co-administration of glutamate with transport inhibitors and clearly revealed the ability of the blockers to exacerbate excitotoxic injury in both in vitro and in vivo models (McBean & Roberts, 1985, Robinson et al., 1993a). In addition to demonstrating the c
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C steroids and their glycosylation products distribute widel
2021-10-25
C21 steroids and their glycosylation products distribute widely in Asclepiadaceae plants. Their anticancer activities have been shown in different human cell lines and in vivo animal experiments [[27], [28], [29], [30], [31], [32]]. However, the mechanisms of their anticancer activities are still un
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vorapaxar mg SCPNs and CPNs exhibit similar
2021-10-25
SCPNs and CPNs exhibit similar strength of electrical coupling (Maruoka et al., 2017) and had similar membrane properties (Experimental Procedures), and showed no significant difference in amplification and synchronization (Figs. 2E and 3C). However, a subset of CPNs exhibit very strong electrical c
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We thus asked whether enhanced
2021-10-23
We thus asked whether enhanced AEA levels in the Irinotecan HCl Trihydrate reduce the level of age-related inflammatory changes and slow down brain ageing. To answer this question we compared the morphology of microglia and level of pro-inflammatory cytokines in the hippocampus of young and old wild
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Thus far it is reported that the histone
2021-10-23
Thus far, it is reported that the histone methyltransferase activity of SUV39H1 is regulated through some posttranslational modifications. For example, deacetylation of SUV39H1 at Lys-266 by SIRT1 deacetylase increases SUV39H1 activity [31], and methylation of SUV39H1 at Lys-105 and Lys-123 by SET7
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Taken together our results indicate that
2021-10-23
Taken together, our results indicate that HSF1 and NRF2 reciprocally regulate HO-1 expression. Although each of HSF1 and NRF2 controls a distinct cytoprotective pathway, mounting evidence points that they engage in crosstalk [15,22]. The protein-protein interaction between HSF1 and NRF2 may be inter
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In addition to changes in the Rho isoforms all
2021-10-23
In addition to changes in the Rho isoforms, all Rac isoforms, including the constitutively active splice variant of Rac1, Rac1b, are overexpressed in various tumors and accumulating evidence indicates that they play an important role in the metastatic potential of cancer Celecoxib (Chan et al., 2005
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To characterize the binding receptor for HIV
2021-10-23
To characterize the binding receptor for HIV-1 gp120 in autophagy, we used the CXCR4 inhibitor AMD3100 and NMDA receptor inhibitor MK801 along with gp120 to treat the cardiomyocytes. Our data demonstrated that inhibition of the NMDA receptor significantly blocked the increase of gp120 induced autoph
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glucokinase br Methods and materials br Results and discussi
2021-10-23
Methods and materials Results and discussion Conclusions This is the first study that attempted to isolate, purify and identify the characteristics of glucokinase from ginseng. In vitro studies have demonstrated that PGL-1 efficiently suppressed SH-SY5Y cell apoptosis induced by Aβ25–35, p
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atp citrate lyase Introduction Histamine was generally acce
2021-10-23
Introduction Histamine was generally accepted as a neurotransmitter in 1984, when histamine was first identified to be located in tuberomamillary nucleus (TM) of the brain (Watanabe et al., 1984). In mammals, histaminergic neurons play an important role in regulating multiple physiological activiti
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