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Taniyama et al reported a female with
2023-10-19
Taniyama et al. reported a female with infertility who had a homozygous T-to-A transversion at nucleotide position g.2472 in exon 3 of the CYP17A1 gene (mutation Y201N) and decreased 17-hydroxylase and 17,20-lyase activities of Fmoc-Ile-Wang resin sale was initiated using dexamethasone to control a
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Tumor suppressor ARF regulates the activity of p by
2023-10-19
Tumor suppressor ARF regulates the activity of p53 by inhibiting the functions of Mdm2. ARF is induced by hyperproliferative signals emanating from oncogenic Ras, overexpressed c-myc, and from deregulated E2F . ARF prevents p53 degradation and leads to increased p53 function by sequestering Mdm2 to
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Knowledge about adipose tissue has evolved considerably over
2023-10-19
Knowledge about adipose tissue has evolved considerably over the last two decades. Always been described as an inert tissue having the function of stocking lipids, adipose tissue is now recognized as a real organ with both metabolic and endocrine functions secreting various factors into the blood to
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br Conclusions In summary aromatase mRNA expression
2023-10-19
Conclusions In summary, aromatase mRNA expression in the Ezatiostat of A. leptorhynchus shows a similar distribution pattern as seen in other teleosts with expression detected in the forebrain and the pituitary gland. The lack of aromatase mRNA expression in the midbrain and hindbrain of A. lept
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br Materials and methods br Results and
2023-10-19
Materials and methods Results and discussion Conclusion Funding This work was supported by the Canadian Institute of Health Research (CIHR) [grant number FDN-148413] to PS, the National Science and Engineering Research Council of Canada (NSERC) [grant number CRD-399680] to ÉM, and the FR
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br Antioxidant polymers conjugates Natural antioxidants are
2023-10-19
Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic LY335979 as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Sing and K
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Analysis of the crystal structures of LAPs from
2023-10-18
Analysis of the crystal structures of LAPs from E. coli[29], bovine eye lens [30], Pseudomonas putida[27], tomato [31] and P. falciparum[32] revealed that the monomer of M17-family LAP is composed of two domains: the smaller, variable N-terminal domain and the larger, conserved C-terminal domain tha
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br Materials and methods br
2023-10-18
Materials and methods Results Table 1 presents the metabolic phenotype of obese minipigs. After 60 d of HFHS feeding, minipigs not only showed an increased body weight (+45%), but also a perturbed Pifithrin-μ australia homeostasis, with higher insulin levels (about +2-fold), HOMA-IR (+5.5-fol
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Tension within the network could be explained by
2023-10-18
Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling labetalol hydrochloride filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin
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lomitapide In these experiments recordings were performed
2023-10-18
In these experiments, recordings were performed continuously in the homecage and during the first 5 days of training on a randomized forced alternation T-maze working memory task (Figures 1A, 1B, 3A, and 3B) (Kucewicz et al., 2011). Sleep and wake states were determined by simultaneous recording of
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Regarding androgens it is known that they are
2023-10-18
Regarding androgens, it is known that they are also essential for reproductive success (Walters et al., 2010). At the molecular level, their effects are produced mainly by dihydrotestosterone (DHT), arising from the conversion of testosterone by the enzyme 3-oxo-5-alpha-steroid-4-dehydrogenase (enco
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Mistletoe is universal name for various
2023-10-18
Mistletoe is universal name for various species of parasitic plant which grows attached to and within the branches of host trees such as apple, elm, oak and pine. Mistletoe extract prepared from Viscum album, a species of mistletoe in the family Santalaceae, is generally known as European mistletoe
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Treatment of all of the GYN
2023-10-18
Treatment of all of the GYN cancer Guanethidine Sulfate synthesis in this study with ATRi not only reduced phosphorylation of Chk1 at Ser345 following genotoxic stress, but also phosphorylation of ATM. Loss of phospho-ATM following ATRi treatment is not likely due to non-specific targeting of ATM b
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The approach of enzymatically converting an analyte and dete
2023-10-18
The approach of enzymatically converting an analyte and detecting it by the resulting small pH changes near the reduced graphene oxide (rGO) surface has successfully been pursued in case of urea (Piccinini et al., 2017). Furthermore, this work reported that electrostatic layer-by-layer (LbL) assembl
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Purvalanol B As with most G protein coupled
2023-10-18
As with most G protein-coupled receptors (GPCRs), sustained activation of APJ can cause desensitization and this has been reported to occur for APJ-mediated effects on cytoplasmic Ca2+ concentration, as well as for effects on activity of adenylyl cyclase, ERK and Akt (Ishida et al., 2004, Masri et a
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