• Several bacterial functional pathways were observed after

  2022-07-06

  

  Several bacterial functional pathways were observed after DON administration, of which signal transduction, metabolism and genetic information processing displayed the highest levels of enrichment. Importantly, these three pathways were reported to be closely associated with DON's toxicity. Many evi

• eicosapentaenoic acid br Conclusions br Acknowledgements Thi

  2022-07-06

  

  Conclusions Acknowledgements This work was supported by grants from the Polish National Science Center: 2014/14/E/NZ1/00139 (to A. Jazwa-Kusior) and 2015/17/N/NZ1/00041 (to M. Tomczyk) and National Centre for Research and Development (STRATEGMED2/269415/11/NCBR/2015) (to J. Dulak). Faculty of

• br Conclusion The following is the supplementary data relate

  2022-07-06

  

  Conclusion The following is the supplementary data related to this article. Conflict of interest Author contributions Heart transplantation is the most important treatment for end-stage heart failure. Ischemia/reperfusion injury is a common condition during transplantation surgery and is

• PDEs a group of metallophosphohydrolases hydrolyze the cycli

  2022-07-06

  

  PDEs, a group of metallophosphohydrolases, hydrolyze the 3′,5′-cyclic phosphate group on cyclic nucleotides to a 5′-monophosphate, thereby blocking cyclic AMP (cAMP) or cGMP signaling [8,9]. There are different types of PDE isozymes, with different substrate specificities. PDE5 (specific to cGMP) an

• Some biguanides can cross the mitochondrial membrane

  2022-07-06

  

  Some biguanides can cross the mitochondrial membrane and increase L-lactate formation by inhibiting oxidative IOX4 receptor [34]. On the other hand, it has also been reported that levels of fasting plasma lactate in T2DM patients are similar regardless of whether or not metformin is administered [3

• br Discovery of GPR A The murine niacin receptor protein

  2022-07-06

  

  Discovery of GPR109A The murine niacin receptor, protein upregulated in macrophages by interferon-γ (PUMA-G), was identified as a G-protein-coupled receptor (GPCR) expressed in adipocytes and spleen [22], [23]. This finding suggested a role of this receptor in macrophage function [24]. In 2003, t

• The aims of the present study

  2022-07-06

  

  The aims of the present study were to further investigate the localisation of glycine and GABAA receptors on individual neurons and how closely these two receptor types were associated with each other by carrying out double immunofluorescent labelling and imaged using confocal laser scanning microsc

• By contrast pentameric glycine receptors GlyR

  2022-07-06

  

  By contrast, pentameric glycine receptors (GlyR) in humans have four functional subunits, α1− α3 and β (Lynch, 2004) whereas the retina of other mammals have an additional α4 subunit (Harvey et al., 2000), and in humans the α4 subunit is considered a pseudogene as it lacks the 4th transmembrane doma

• Young et al described the

  2022-07-06

  

  Young et al. [40] described the role of adenine monophosphate-activated protein kinase (AMPK) in the translocation of GLUT4 in the heart. The AMPK is activated during muscle contraction [74] by converting AMP to ATP. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a c

• br Conclusion In conclusion SHP

  2022-07-06

  

  Conclusion In conclusion, SHP289-04 was demonstrated as a potent glucokinase activator. It could normalize the blood glucose level and lipid level in spontaneous type 2 diabetes model KKAy mice. At the same time, it ameliorated the function of islets and liver in KKAy mice. It had been proved to

• Some of the key aspects of the

  2022-07-06

  

  Some of the key aspects of the myofibroblasts’ biology, including their signaling sensitivity and residual regenerative potential, are shaped by their origin. In this respect, lineage studies on myofibroblast precursors are critical for increasing our understanding of the natural history of fibrosis

• Piezo channels can be activated by

  2022-07-06

  

  Piezo channels can be activated by many mechanical stimuli . While some of these stimulations directly mimic physiological forces experienced by LY2940680 receptor , such as shear stress applied in a microfluidic chamber, the most commonly used modes of stimulation consist of stretching the membra

• br Concluding remarks In this small

  2022-07-06

  

  Concluding remarks In this small material of thirteen pituitary tumors of various kinds, we could not run statistical analysis. However, with a follow-up period of up to five years, we show that Disclosure Statement Acknowledgments Introduction Galanin is a 29/30-residue neuropeptide fo

• cetp inhibitor Prion diseases are transmissible and result i

  2022-07-05

  

  Prion diseases are transmissible and result in fatal neurodegenerative disorders, which, similar to AD, also involve the infiltration and activation of mononuclear phagocytes in cetp inhibitor lesions (reviewed in [61]). A 21 amino-acid fragment of the aberrant human prion protein, Prp106–126, can f

• br Role of FPRs in regulating the

  2022-07-05

  

  Role of FPRs in regulating the inflammatory response Annexin I is a glucocorticoid-regulated protein possessing both pro- and anti-inflammatory activity that might be mediated, in part, by FPR activation [35]. Expressed in a variety of cell types, annexin I is particularly abundant in neutrophil

15948 records 426/1064 page Previous Next First page 上5页 426427428429430 下5页 Last page